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Roos, Raymond P.
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overview Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.
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Concept Amyotrophic Lateral Sclerosis
Academic Article Home ventilation for amyotrophic lateral sclerosis patients: outcomes, costs, and patient, family, and physician attitudes.
Academic Article Patients with amyotrophic lateral sclerosis receiving long-term mechanical ventilation. Advance care planning and outcomes.
Academic Article Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection.
Academic Article Amyotrophic lateral sclerosis and viruses.
Academic Article The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis.
Academic Article Intrafamilial heterogeneity in hereditary motor neuron disease.
Academic Article A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy.
Academic Article Failure to detect poliovirus genetic information in amyotrophic lateral sclerosis.
Academic Article Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method.
Academic Article Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord.
Academic Article Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants.
Academic Article Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Academic Article Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.
Academic Article Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.
Academic Article Mutant SOD1 forms ion channel: implications for ALS pathophysiology.
Academic Article Amyotrophic lateral sclerosis with antecedent poliomyelitis.
Academic Article Coexistence of amyotrophic lateral sclerosis and Werdnig-Hoffmann disease within a family.
Academic Article Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice.
Academic Article Neuromuscular transmission in amyotrophic lateral sclerosis.
Academic Article The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis.
Academic Article The unfolded protein response in familial amyotrophic lateral sclerosis.
Academic Article Linkage analysis in familial amyotrophic lateral sclerosis.
Academic Article Nucleic acid probes in the study of amyotrophic lateral sclerosis.
Academic Article Circulating immune complexes in neurologic disease.
Academic Article No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis.
Academic Article Amyotrophic lateral sclerosis and life-sustaining therapy: patients' desires for information, participation in decision making, and life-sustaining therapy.
Academic Article Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Academic Article Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.
Academic Article Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.
Academic Article Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.
Academic Article Venous thromboembolism after diaphragm pacing in amyotrophic lateral sclerosis.
Academic Article Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis.
Academic Article An enhanced integrated stress response ameliorates mutant SOD1-induced ALS.
Academic Article Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment.
Academic Article Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis.
Academic Article S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.
Academic Article Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS.
Academic Article Evidence for an early innate immune response in the motor cortex of ALS.
Academic Article TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Academic Article Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS.
Academic Article Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice.
Academic Article Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Academic Article A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Academic Article Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions.
Academic Article Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons.
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  • Amyotrophic Lateral Sclerosis